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Uric Acid and Clinical Outcomes in Young Patients with Ischemic Stroke

Yanfang Liu1,2,3, Xinmin Liu1,2, Jiaokun Jia1,2,3

  • 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.

Neuropsychiatric Disease and Treatment
|October 6, 2022
PubMed

Insights

Higher uric acid (UA) levels in young adults were linked to less severe strokes and reduced pneumonia risk. However, UA levels did not predict long-term functional outcomes after acute ischemic stroke (AIS).

Area of Science:

  • Neurology
  • Biochemistry
  • Public Health

Background:

  • Limited evidence exists on uric acid (UA) levels and ischemic stroke in young adults.
  • Acute ischemic stroke (AIS) in young patients (18-45 years) requires further investigation regarding risk factors and outcomes.
  • Understanding the role of UA in AIS is crucial for this demographic.

Purpose of the Study:

  • To explore the association between serum uric acid levels and acute ischemic stroke (AIS) in young patients.
  • To determine if UA levels predict functional outcomes, stroke severity, or in-hospital complications in young AIS patients.

Main Methods:

  • A prospective, observational study included 636 young patients (18-45 years) with AIS.
  • Patients were grouped into quartiles based on serum UA levels.
  • Functional outcomes (Modified Rankin Scale), stroke severity (NIHSS), and complications were assessed.

Main Results:

  • Higher UA levels were negatively associated with moderate-to-severe stroke (NIHSS≥5) at admission (p for trend =0.016).
  • Increased UA levels significantly reduced the risk of in-hospital pneumonia (p for trend < 0.0001).
  • UA levels did not significantly predict functional outcomes at discharge or 3 months post-AIS.

Conclusions:

  • Serum UA may act as a protective factor against stroke severity and in-hospital pneumonia in young AIS patients.
  • The predictive significance of UA for functional outcomes in this population remains unclear.
  • Further research is needed to elucidate the role of UA in the pathophysiology and prognosis of AIS in young adults.
Abstract

Keywords:
complicationoutcomestroke severityuric acidyoung ischemic stroke

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