Related Experiment Video
Updated: Aug 26, 2025
09:17
Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification
Published on: July 12, 2019
8.9K
Super Digit: More Than a Complicated Syndactyly.
Mariana Agostinho1, Vera Eiró1, Tatiana Gomes1
1Plastic and Reconstructive Surgery, Centro Hospitalar Lisboa Ocidental, Lisbon, PRT.
Cureus
|October 6, 2022
Summary
Super digits are rare hand malformations. This study revises classification for better identification, particularly noting they are a contraindication for syndactyly release surgery.
Area of Science:
- Hand surgery
- Congenital malformations
- Pediatric orthopedics
Background:
- Super digits are rare congenital hand anomalies.
- Previous surgical approaches for super digits have been discouraged.
- Classification of super digit subtypes is critical for treatment planning.
Observation:
- A variant of a super digit type IC2 was identified.
- The presented case highlights the need for refined classification criteria.
- Existing descriptions may not fully capture the spectrum of super digit presentations.
Findings:
- A proposed revision to Virchel Wood's original super digit subtype characteristics is presented.
- The revised classification aims to improve the accurate identification of super digits.
- Specific subtypes require distinct management considerations.
Implications:
- Accurate identification of super digits is crucial as they contraindicate syndactyly release.
- Revised classification may guide surgical decision-making in complex hand anomalies.
- This work could enhance the understanding and treatment of super digit malformations.
Related Concept Videos
01:17Muscles of the Forearm that Move the Hand and Fingers
1.3K
The muscles of the forearm that move the wrist, hand, and digits are numerous and diverse. They can be classified into two groups based on their location and function — the anterior and posterior compartment muscles.
Anterior Compartment
The anterior compartment muscles originate from the humerus. They primarily function as flexors and are also known as flexor muscles. They typically insert on the carpals, metacarpals, and phalanges. The superficial layer includes the flexor carpi...
Anterior Compartment
The anterior compartment muscles originate from the humerus. They primarily function as flexors and are also known as flexor muscles. They typically insert on the carpals, metacarpals, and phalanges. The superficial layer includes the flexor carpi...
1.3K
02:04Polytene Chromosomes
10.2K
Polytene chromosomes are giant interphase chromosomes with several DNA strands placed side by side. They were discovered in the year 1881 by Balbiani in salivary glands, intestine, muscles, malpighian tubules, and hypoderm of larvae Chironomus plumosus. Hence, these are also called "Salivary gland chromosomes." These are found in insects of the order Diptera and Collembola; in certain organs of mammals; and synergids, antipodes of flowering plants. Polytene chromosomes are also...
10.2K
01:21Nondisjunction
4.0K
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers. Nondisjunction is common during anaphase I or anaphase II of meiosis. Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
4.0K
01:05Desmosomes
5.6K
The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein...
5.6K
01:09Changes in the Appendicular Skeleton with Age
2.2K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
2.2K
01:57Protein Complexes with Interchangeable Parts
2.6K
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
2.6K