Related Experiment Video
Updated: Aug 26, 2025
09:01
Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
14.1K
Acute Myeloid Leukemia in a Cholecystectomy Specimen
Ana I Hernandez Caballero1, Eduardo Castro-Echeverry1, Roula Katerji2
1Department of Pathology, Baylor Scott and White Healthcare, Temple, TX, USA.
Case Reports in Pathology
|October 6, 2022
Summary
A rare case of acute myeloid leukemia (AML) presented with gallbladder inflammation. The leukemia cells were incidentally discovered during surgery for gallstones, highlighting an unusual clinical presentation of AML.
Area of Science:
- Gastroenterology
- Hematology
- Oncology
Background:
- Acute cholecystitis is commonly caused by gallstones.
- Gallbladder wall infiltration by myeloid precursors is exceedingly rare.
Observation:
- A 76-year-old man presented with acute cholecystitis and gallstones.
- Surgical specimen revealed atypical cells infiltrating the gallbladder wall and vasculature.
- Immunohistochemistry confirmed myeloid origin (CD117+, CD43+, myeloperoxidase+).
Findings:
- The patient was diagnosed with acute myeloid leukemia (AML).
- Circulating immature myeloid precursors constituted 38% of peripheral blood events.
- Gallbladder involvement served as the initial clinical manifestation of AML.
Implications:
- This case underscores the importance of thorough pathological examination of gallbladder specimens.
- It highlights an unusual presentation of acute myeloid leukemia.
- Early detection of AML through incidental findings can improve patient outcomes.
