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Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: Aug 26, 2025

Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
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Granular cell dermatofibroma: A potential diagnostic pitfall.

Gerardo Cazzato1, Anna Colagrande1, Teresa Lettini1

  • 1Department of Emergency and Organ Transplantation-Pathology Unit, University of Bari Aldo Moro, Italy.

Dermatology Reports
|October 6, 2022
PubMed
Summary
This summary is machine-generated.

Dermatofibromas, common skin tumors, have many variants. Recognizing these variations, like the granular cell type, is crucial for accurate diagnosis and avoiding misclassification of aggressive tumors.

Keywords:
DermatofibromaGranular cellHistiocytomaImmunohistochemistrySkin

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Isolation of Papillary and Reticular Fibroblasts from Human Skin by Fluorescence-activated Cell Sorting
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Area of Science:

  • Dermatopathology
  • Oncology

Background:

  • Dermatofibroma, also known as fibrous histiocytoma, is a frequent cutaneous soft-tissue tumor.
  • Numerous variants exist, necessitating awareness to prevent misdiagnosis of potentially aggressive neoplasms.
  • While typical features are often present, cellular variations can complicate histopathological diagnosis.

Purpose of the Study:

  • To highlight the importance of recognizing dermatofibroma variants.
  • To discuss the diagnostic challenges posed by atypical cellular changes.
  • To report a case of the granular cell variant of cutaneous fibrous histiocytoma.

Main Methods:

  • Histopathological examination of a cutaneous lesion.
  • Immunohistochemical investigations for definitive classification (implied).

Main Results:

  • A case of the rare granular cell variant of cutaneous fibrous histiocytoma was identified.
  • The lesion was located on the left leg of a 74-year-old female patient.

Conclusions:

  • Accurate histopathological classification of dermatofibroma variants is essential.
  • Immunohistochemistry may be required for complex cases with significant cellular atypia.
  • Awareness of variants like the granular cell type aids in appropriate patient management.