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Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice
Published on: March 29, 2024
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Aerobic Exercise Training Improves Microvascular Function and Oxidative Stress Parameters in Diet-Induced Type 2
Karine Lino Rodrigues1, Vivian Vieira Dias Da Silva1, Evelyn Nunes Goulart da Silva Pereira1
1Laboratory of Cardiovascular Investigation, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, RJ, Brazil.
Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
|October 6, 2022
Summary
Aerobic exercise improves liver and white adipose tissue microcirculation in type 2 diabetes (T2D) by reducing AGE-RAGE axis activation and enhancing antioxidant activity. This physical training helps mitigate metabolic dysfunction and disease progression in T2D.
Area of Science:
- Metabolic Physiology
- Exercise Science
- Vascular Biology
Background:
- Type 2 diabetes (T2D) is characterized by microcirculatory disturbances in the liver and white adipose tissue (WAT), contributing to metabolic dysfunction.
- The impact of aerobic training on these specific microcirculatory systems and their underlying mechanisms in T2D remains largely unexplored.
Purpose of the Study:
- To investigate the effects of aerobic training on liver and WAT microcirculation in a mouse model of T2D.
- To elucidate the role of the AGE-RAGE axis and antioxidant activity in mediating these training adaptations.
Main Methods:
- T2D was induced in mice using a high-fat, high-carbohydrate diet.
- Mice underwent a 12-week aerobic training program or remained sedentary.
- Evaluated metabolic parameters, AGE-RAGE axis, hepatic steatosis, hepatic stellate cell (HSC) activation, and microcirculation in liver and WAT.
Main Results:
- Aerobic training improved hepatic microcirculation in T2D mice, correlating with reduced body/liver/fat mass, improved blood pressure, decreased hepatic steatosis and fibrosis, and suppressed HSC and AGE-RAGE activation.
- In white adipose tissue, training enhanced microcirculation by reducing leukocyte recruitment and increasing perfusion, linked to elevated catalase antioxidant activity.
Conclusions:
- Aerobic training effectively ameliorates hepatic and adipose tissue microcirculatory dysfunction in T2D.
- These improvements are attributed to the downregulation of the AGE-RAGE axis, reduced HSC activation, and increased antioxidant capacity.
