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Gut Microbiota and Colorectal Cancer Risk Factors
Hadi Feizi1,2,3, Mohammad Ahangarzadeh Rezaee1, Reza Ghotaslou1
1Drug Applied Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Current Pharmaceutical Biotechnology
|October 6, 2022
Summary
Gut microbiome alterations are common in colorectal cancer (CRC) and may link risk factors to cancer development. This review explores bacteriome changes and their role in CRC progression.
Area of Science:
- Gastroenterology
- Microbiology
- Oncology
Background:
- Colorectal cancer (CRC) incidence is influenced by genetic and environmental factors, including the gut microbiome.
- Alterations in gut microbiota, particularly bacteriomes, are frequently observed in CRC patients.
- The precise role of these microbial changes—whether causal or consequential—in CRC development requires further investigation.
Purpose of the Study:
- To review risk factors for colorectal cancer (CRC), focusing on gut bacteriomes and their interactions.
- To explore the association between gut microbial dysbiosis and CRC development.
Main Methods:
- Literature review of studies investigating gut microbiota and colorectal cancer.
- Analysis of the role of bacterial genotoxicity, biofilm formation, oxidative stress, and metabolomics in CRC.
Main Results:
- Gut bacteriome alterations are a common feature across various CRC risk factors.
- These microbial changes are nearly universal among individuals affected by CRC.
- Mechanisms such as bacterial genotoxicity and dysbiosis are implicated in CRC pathogenesis.
Conclusions:
- Gut microbial alterations may act as a crucial intermediate, either as a cause or consequence, linking CRC risk factors to cancer development.
- Understanding these microbial dynamics is key to deciphering CRC etiology.
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