Related Experiment Video
Updated: Aug 26, 2025

05:15
Isolation of Intact Eyeball to Obtain Integral Ocular Surface Tissue for Histological Examination and Immunohistochemistry
Published on: October 20, 2019
8.6K
Epigenetics in Eye Development and Ocular Disorders: A Brief Review
Raja Amir Hassan Kuchay1, Asima Hassan2, Yaser Rafiq Mir1
1Department of Biotechnology, Baba Ghulam Shah Badshah University, Rajouri, J&K, India.
Current Molecular Medicine
|October 6, 2022
Summary
Epigenetics influences gene expression and is linked to various disorders. This review explores how epigenetic mechanisms impact eye development and ocular diseases like glaucoma and macular degeneration.
Area of Science:
- Molecular Biology
- Genetics
- Ophthalmology
Background:
- Epigenetics regulates gene expression by altering chromatin structure.
- Epigenetic alterations are implicated in developmental pathways and human diseases.
- The role of epigenetics in eye development and ocular disorders is an emerging area of research.
Approach:
- This review discusses the relevance of epigenetic mechanisms.
- Focuses on DNA methylation, histone modifications, polycomb proteins, and noncoding RNAs.
- Examines their role in eye development and specific ocular disorders.
Key Points:
- Epigenetic mechanisms are crucial for normal eye development.
- Aberrant epigenetic changes contribute to ocular pathologies.
- Specific epigenetic factors like DNA methylation and noncoding RNAs are key players.
Conclusions:
- Epigenetic modifications are integral to eye development.
- Understanding these mechanisms offers potential therapeutic targets for ocular diseases.
- Further research is needed to fully elucidate the epigenetic landscape of eye disorders.
Related Concept Videos
Genetic Lingo
103.9K
Overview
103.9K
Photoreceptors and Visual Pathways
6.3K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.3K
Accessory Structures of the Eye
1.7K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
1.7K
Genomic Imprinting and Inheritance
35.0K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
35.0K
Human Genetics
687
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
687

