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A Number of the N-terminal RASSF Family: RASSF7

Yang Xu1,2, Wei Du3, Yongshuang Xiao1

  • 1Department of Urology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, People's Republic of China.

Anti-Cancer Agents in Medicinal Chemistry
|October 6, 2022
PubMed

Insights

Ras association domain family 7 (RASSF7) is implicated in various cancers. This review explores RASSF7

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Ras association domain family 7 (RASSF7), also known as HRC1, is located on human chromosome 11p15.
  • RASSF7 is a key member of the N-terminal RASSF family with a potential role in tumorigenesis.
  • The precise molecular mechanisms of RASSF7 in cancer development require further elucidation.

Purpose of the Study:

  • To systematically review the literature on RASSF7's role in tumorigenesis.
  • To elaborate on RASSF7's structure, biomechanisms, and signaling pathways.
  • To assess RASSF7 as a potential therapeutic target for human malignancies.

Main Methods:

  • Systematic literature review of PUBMED and MEDLINE databases.
  • Assessment of existing research on RASSF7's biological functions and involvement in cancer.
  • Analysis of RASSF7's regulatory roles in key cellular processes and signaling pathways.

Main Results:

  • RASSF7 significantly influences mitosis, microtubule growth, apoptosis, proliferation, and differentiation.
  • RASSF7 can promote tumor development by regulating pathways involving Aurora B, MKK4/7, JNK, YAP, MEK, and ERK.
  • RASSF7 may inhibit tumorigenesis by suppressing c-Myc, and its dysregulation is observed in lung, breast, and gastric cancers, among others.
  • RASSF7 expression correlates positively with tumor TNM stage.

Conclusions:

  • RASSF7 plays a multifaceted role in cancer, potentially acting as both an oncogene and a tumor suppressor depending on the context.
  • Understanding RASSF7's complex regulatory networks is crucial for developing targeted cancer therapies.
  • RASSF7 represents a promising therapeutic target for various human malignancies.
Keywords:
CpG islandsN-terminal.RASSF7malignancytherapeutic targettumor promoter

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