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Updated: Aug 26, 2025

Fluorescence-Activated Cell Sorting for the Isolation of Scleractinian Cell Populations
Published on: May 31, 2020
A new cembranoid from the Red Sea soft coral Sarcophyton acutum
Tarik A Mohamed1, Seba M Abdelmawgoud2, Abdelhamid A Hamdy2
1Chemistry of Medicinal Plants Dept, Chemistry of Medicinal Plants, Dokki, Giza, Egypt.
Abstract:
The Red Sea soft coral Sarcophyton acutum ethyl acetate extract has afforded one new cembranoid; sarcacutumolid A (1), along with six known metabolites have been isolated from S. acutum for the first time (2-7). Chemical structures were elucidated by employing several spectroscopic analyses. The cytotoxic potential of the isolated compounds was assessed against four human cancer cell lines; hepatocellular (HepG2), cervical (HeLa), breast (MCF-7) and colorectal cancer (Colo-205). Sarcacutumolid A (1) and gorgosterol (7) inhibited colorectal cancer cell proliferation in a concentration-dependent manner with IC50 values of 35.5 and 44.0 μM, respectively.
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