Thais savignyi tissue extract: bioactivity, chemical composition, and molecular docking

Area of Science:

• Marine Biology
• Pharmacology
• Natural Products Chemistry

Background:

• Thais savignyi, a Red Sea mollusk, is abundant and has historical use in traditional medicine.
• Investigating marine organisms for novel therapeutic compounds is crucial for drug discovery.

Purpose of the Study:

• To determine the chemical profile and biological activities of Thais savignyi tissue extracts.
• To evaluate the antioxidant, antimicrobial, antibiofilm, and cytotoxic properties of T. savignyi extracts.

Main Methods:

• Extraction of T. savignyi tissue using methanol, ethanol, acetone, and ethyl acetate.
• Assessing antioxidant capacity, DPPH radical scavenging, total phenolic content, and antimicrobial/antibiofilm activity against various pathogens.
• Evaluating cytotoxicity against human cancer cell lines and performing GC-MS analysis and molecular docking.

Main Results:

• The ethyl acetate extract (Ts-EtOAc) demonstrated potent antioxidant, antimicrobial (e.g., against K. pneumoniae), antibiofilm (e.g., against S. aureus), and antifungal (e.g., against C. albicans) activities.
• Ts-EtOAc exhibited significant cytotoxicity against UO-31 and A549 cancer cell lines.
• GC-MS analysis identified diverse bioactive metabolites, and molecular docking suggested antibacterial potential.

Conclusions:

• Thais savignyi extracts possess notable antimicrobial and cytotoxic properties, indicating potential for pharmaceutical applications.
• Further isolation and characterization of active constituents from T. savignyi are warranted for comprehensive drug development.