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Acute periapical abscesses in patients using selective serotonin reuptake inhibitors
1Department of Endodontics, University of Southern California, Los Angeles, California, USA.
Summary
Patients using Selective Serotonin Reuptake Inhibitors (SSRIs) have a significantly higher prevalence of periapical abscesses (PAs). This study found a 2.8 times greater odds of developing PAs in SSRI users compared to non-users.
Area of Science:
- Pharmacology
- Oral Health
- Psychiatry
Background:
- Depression and anxiety are global health concerns, leading to increased antidepressant use.
- Selective Serotonin Reuptake Inhibitors (SSRIs) are commonly prescribed due to a favorable side effect profile.
- The potential oral health implications of SSRI use require investigation.
Purpose of the Study:
- To determine the prevalence of periapical abscesses (PAs) in patients undergoing treatment with SSRIs.
- To assess the association between SSRI usage and the occurrence of acute PAs.
Main Methods:
- Retrieved integrated hospital patient data using ICD-10 codes for SSRIs and acute PAs.
- Diagnoses were confirmed by calibrated dentists via clinical examination and imaging.
- Statistical analysis, including odds ratio calculation, was performed to determine the association.
Main Results:
- The prevalence of acute PAs was significantly higher in patients using SSRIs.
- The odds ratio (OR) for acute PAs in SSRI users was 2.8.
- The observed difference was statistically significant (p < .0001).
Conclusions:
- Patients using SSRIs exhibit a higher prevalence of acute periapical abscesses.
- This finding suggests a potential link between SSRI medication and the development of PAs.
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