Methadone-induced hypoglycemia: A case report

Area of Science:

• Endocrinology
• Pharmacology
• Internal Medicine

Background:

• Hypoglycemia is a rare condition in patients without diabetes mellitus.
• Methadone, a synthetic μ-opioid receptor agonist, is widely used for pain management and opioid dependence treatment.

Observation:

• A 31-year-old male patient experienced recurrent episodes of hypoglycemia.
• These hypoglycemic events ceased after the discontinuation of methadone therapy.

Findings:

• The case suggests a potential link between methadone use and the occurrence of hypoglycemia in non-diabetic individuals.
• Resolution of hypoglycemia upon methadone cessation indicates a possible causal relationship.

Implications:

• Clinicians should consider methadone as a potential cause of hypoglycemia in patients presenting with unexplained low blood sugar.
• Reducing methadone dosage or switching to an alternative opioid may be warranted before extensive investigations for hyperinsulinism.
• This finding highlights the importance of a thorough medication review in managing unexplained hypoglycemia.