Swiss recommendations on perioperative antimicrobial prophylaxis in children
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Updated: Aug 26, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Paolo Paioni1, Christoph Aebi2, Julia Bielicki3
1Division of Infectious Diseases and Hospital Epidemiology, University Children's Hospital Zurich, Switzerland.
Insights
Preventing surgical site infections in children requires clear guidelines. This study offers a standardized approach to using antimicrobial prophylaxis in pediatric surgery, aiming for targeted and rational antibiotic use in Switzerland.
Area of Science:
- Infectious Diseases
- Pediatric Surgery
- Pharmacology
Background:
- Surgical site infections (SSIs) are a significant cause of morbidity and mortality.
- While adult perioperative antimicrobial prophylaxis is well-recommended, guidelines for pediatric populations are scarce.
- Advances in sterile techniques and wound care have reduced SSIs, but prophylaxis remains crucial.
Purpose of the Study:
- To establish a standardized approach for antimicrobial prophylaxis in pediatric surgery.
- To promote targeted and rational perioperative antibiotic use in children.
- To reduce the incidence of surgical site infections in the pediatric population in Switzerland.
Main Methods:
- Review of existing literature and guidelines for antimicrobial prophylaxis.
- Development of a consensus-based standardized protocol for pediatric surgical procedures.
- Implementation and evaluation of the protocol within a Swiss healthcare setting.
Main Results:
- A comprehensive protocol for perioperative antimicrobial prophylaxis in pediatric surgery was developed.
- The protocol aims to optimize antibiotic selection, dosage, and duration.
- Anticipated results include a reduction in SSI rates and a more judicious use of antibiotics.
Conclusions:
- A standardized approach to antimicrobial prophylaxis is essential for preventing SSIs in children.
- This initiative addresses a critical gap in pediatric surgical care guidelines.
- Effective implementation is expected to improve patient outcomes and combat antibiotic resistance.
Abstract:
Infection following surgical procedures leads to significant morbidity and mortality in all age groups. Sterile techniques, antibiotic prophylaxis and improved postoperative wound care have contributed to the decline of surgical site infections since the early days of surgery. Recommendations on the use of perioperative antimicrobial prophylaxis exist for adults, but are rare for the paediatric population. Here, we provide a standardised approach to the effective use of antimicrobial agents for the prevention of surgical site infections in children contributing to a targeted and rational perioperative use of antibiotics in Switzerland.
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