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Bleeding risk of oral anticoagulants in liver cirrhosis

Oriana Munevar Aquite1, Michael Hayes2, Kebede Beyene1

  • 1School of Pharmacy, Faculty of Medical and Health Science, The University of Auckland, New Zealand.

The New Zealand Medical Journal
|October 6, 2022
PubMed

Insights

Patients with liver cirrhosis taking dabigatran showed a lower bleeding risk compared to warfarin. However, this difference was not statistically significant in this study.

Area of Science:

  • Hepatology
  • Pharmacology
  • Clinical Medicine

Background:

  • Limited data exists on dabigatran safety in liver cirrhosis patients.
  • Bleeding risks of dabigatran versus warfarin in this population are understudied.

Purpose of the Study:

  • To compare the bleeding risk of dabigatran and warfarin in patients with liver cirrhosis.
  • To evaluate dabigatran safety in patients with liver cirrhosis.

Main Methods:

  • Retrospective cohort study across three tertiary centers (2008-2020).
  • Included adults (18+) with confirmed liver cirrhosis.
  • Primary outcome: hospital-admitted bleeding events.

Main Results:

  • 100 patients included: 52 on warfarin, 48 on dabigatran.
  • Bleeding rate: Warfarin 14.4/100 person-years; Dabigatran 9.1/100 person-years.
  • Incidence rate ratio (Dabigatran vs. Warfarin): 0.63 (p=0.25).

Conclusions:

  • Dabigatran may be associated with a lower bleeding risk than warfarin in liver cirrhosis patients.
  • The observed difference in bleeding risk was not statistically significant.
Abstract

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