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Published on: June 23, 2020
Design and synthesis of silver nanoparticle anchored poly(ionic liquid)s mesoporous for controlled anticancer drug
Ehsan Aliakbari1, Yahya Nural2, Reza Eghdam Zamiri3
1Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract:
Owing to the importance of drug delivery, the synthesis of advanced nanomaterials for targeted drug delivery plays a considerable role in medical treatment. One of the most prominent nanomaterials is PIL, which is used as controlled anticancer drug delivery and significantly improves the half-life and antitumor effect. In this study, a stable and effective drug carrier containing silver nanoparticles was reported for the drug delivery with an antimicrobial effect, and the capability of the drug carrier . PILP was synthesized by radical polymerization, and silver nanoparticles were anchored into PIL voids by in-situ reduction, which developed the adsorption antimicrobial effect and capability of the drug carrier. The synthesized nanocomposite was characterized. The Ag-PILP nanocomposite showed antibacterial activityagainst both E. coli and S. aureus with a MIC of 256 μg/mL, and bactericidal activity against E. coli and S. aureus strains with a MBC of 256 and 512 μg/mL, respectively.
