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The role of miRNA-424 and miR-631 in various cancers: Focusing on drug resistance and sensitivity
Fatemeh Najafi1, Shohre Karimi Kelaye2, Bahareh Kazemi2
1Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Background:
However, advanced technologies have been developed in the treatment of various cancers, but the mortality rate from cancer is still very high. Drug resistance is a major problem for patients with cancer, which causes the treatment process to fail. In addition to inhibiting drug resistance, targeted therapy is also very important in treatment.
Main Body:
Nowadays, miRNAs have gained increasing interest as they play a major role in both drug resistance and targeted therapy. MicroRNA (miRNA) is an important part of non-coding RNA that regulates gene expression at a post-transcriptional level. The prevailing studies about miRNA expression have been expanded into a variety of neoplasms. MiR-424 and miR-631 targets genes involved in various cellular processes and can participate in proliferation, differentiation, apoptosis, invasion, angiogenesis, and drug resistance and sensitivity.
Conclusion:
In this study, we focus on the role of miR-424 and miR-631 in many cancer types by displaying the potential target genes associated with each cancer, as well as briefly describing the clinical uses of miR-424 and miR-631 as a diagnostic and predictive tool in malignancies.
Insights
MicroRNAs (miRNAs), specifically miR-424 and miR-631, show promise in overcoming cancer drug resistance and improving targeted therapy. These non-coding RNAs regulate gene expression and can serve as diagnostic and predictive tools in oncology.
Area of Science:
- Molecular Biology
- Oncology
- Genetics
Background:
- Despite advancements, cancer mortality remains high, with drug resistance significantly hindering treatment efficacy.
- Targeted therapy and overcoming drug resistance are critical challenges in modern cancer treatment.
Purpose of the Study:
- To investigate the role of specific microRNAs (miRNAs), namely miR-424 and miR-631, in various cancer types.
- To explore the potential of miR-424 and miR-631 as diagnostic and predictive biomarkers in malignancies.
Main Methods:
- Reviewing current literature on miRNA expression in neoplasms.
- Analyzing the function of miR-424 and miR-631 in regulating gene expression at the post-transcriptional level.
- Identifying potential target genes associated with miR-424 and miR-631 in different cancers.
Main Results:
- MicroRNAs (miRNAs) are crucial regulators of gene expression and play significant roles in both drug resistance and targeted therapy.
- MiR-424 and miR-631 target genes involved in key cellular processes like proliferation, apoptosis, and angiogenesis.
- These miRNAs are implicated in modulating cancer cell drug resistance and sensitivity.
Conclusions:
- MiR-424 and miR-631 are important players in the development and progression of various cancers.
- Understanding the target genes of miR-424 and miR-631 can provide insights into their oncogenic roles.
- MiR-424 and miR-631 hold potential as valuable diagnostic and predictive tools for cancer management.
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