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MoS2 nanoflower-mediated enhanced intratumoral penetration and piezoelectric catalytic therapy
Yaqian He1, Zichuang Xu1, Yuchu He1
1State Key Laboratory of Metastable Materials Science and Technology, Nano-biotechnology Key Lab of Hebei Province, Applying Chemistry Key Lab of Hebei Province, Yanshan University, Qinhuangdao, 066004, PR China.
Abstract:
The absence of lymphatic vessels in tumors leads to the retention of interstitial fluid, and the formation of an inverse pressure difference between the tumor and blood vessels hinders drug delivery deep into the tumor, which leads to tumor recurrence and metastasis. Therefore, we designed a novel strategy to downregulate tumor interstitial fluid pressure (TIFP) by water splitting in the tumor interstitium based on piezoelectric catalysis nanomedicine. First, the chemotherapeutic drug doxorubicin (DOX) was loaded on the piezoelectric catalytic material MoS2 and then encapsulated with tumor cell membrane (CM) to obtain MD@C. MD@C could not only target the tumor through homologous targeting but, more importantly, also triggered piezoelectric catalytic water splitting under ultrasound (US) stimulation; as a result, the TIFPs of U14 and PAN02 tumor-bearing mice were reduced to 57.14% and 45.5%, respectively, and the tumor inhibition rates of MD@C were 96.75% and 99.21%, which increased the perfusion of blood-derived drugs in the tumors. Moreover, the hydroxyl radicals generated by piezoelectric catalysis could effectively inhibit the growth of tumors in combination with DOX. Consequently, the piezoelectric catalytic water splitting strategy of MD@C can enhance drug delivery, providing a new universal platform for the treatment of solid malignant tumors.
Insights
This study introduces a novel nanomedicine strategy using piezoelectric catalysis to reduce tumor interstitial fluid pressure. This approach enhances chemotherapy drug delivery and significantly inhibits solid malignant tumor growth.
Area of Science:
- Biomedical Engineering
- Materials Science
- Oncology
Background:
- Tumor lymphatic vessel absence causes interstitial fluid retention, increasing interstitial fluid pressure.
- Elevated tumor interstitial fluid pressure (TIFP) impedes drug delivery, leading to tumor recurrence and metastasis.
- Developing strategies to reduce TIFP is crucial for effective solid tumor treatment.
Purpose of the Study:
- To design a novel nanomedicine strategy to downregulate TIFP using piezoelectric catalytic water splitting.
- To enhance the delivery of chemotherapeutic drugs into solid tumors.
- To provide a new platform for treating solid malignant tumors.
Main Methods:
- Doxorubicin (DOX) loaded onto molybdenum disulfide (MoS2) and encapsulated with tumor cell membrane (CM) to form MD@C.
- Ultrasound (US) stimulation to trigger piezoelectric catalytic water splitting within the tumor.
- Evaluation of TIFP reduction and tumor inhibition rates in tumor-bearing mice.
Main Results:
- MD@C demonstrated homologous targeting to tumors.
- Piezoelectric catalytic water splitting significantly reduced TIFP in U14 and PAN02 tumors (to 57.14% and 45.5%, respectively).
- MD@C achieved high tumor inhibition rates (96.75% and 99.21%) and enhanced drug perfusion.
Conclusions:
- The MD@C nanomedicine effectively reduces TIFP via piezoelectric catalytic water splitting under ultrasound.
- This strategy enhances chemotherapy drug delivery and exhibits potent anti-tumor effects.
- The piezoelectric catalytic water splitting approach offers a promising universal platform for solid malignant tumor treatment.
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