Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

966
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
966
Neuroplasticity01:01

Neuroplasticity

697
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
697
Neural Regulation01:37

Neural Regulation

39.7K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.7K
Neurotransmitters01:30

Neurotransmitters

3.1K
Neurotransmitters play a crucial role in the communication between neurons in the autonomic nervous system. Neurons in the autonomic nervous system can be cholinergic or adrenergic depending on the neurotransmitters synthesized. Cholinergic neurons use acetylcholine as their primary neurotransmitter. This includes all the preganglionic fibers of the sympathetic and pre- and postganglionic fibers of the parasympathetic nervous systems. In addition, neurons of the somatic nervous system also use...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Direct targeting of C9ORF72 repeat RNA with fluorinated antisense oligonucleotides.

Nucleic acids research·2026
Same author

Epilepsy Research Institute Partner Symposium: Radically advancing research into epilepsy.

Brain and neuroscience advances·2025
Same author

Reprogramming astroglia into neurons with hallmarks of fast-spiking parvalbumin-positive interneurons by phospho-site-deficient Ascl1.

Science advances·2024
Same author

Programming of neural progenitors of the adult subependymal zone towards a glutamatergic neuron lineage by neurogenin 2.

Stem cell reports·2023
Same author

Seizing hope: Advancing cell therapy for pharmaco-resistant epilepsy toward the clinic.

Cell stem cell·2023
Same author

Lmo4 synergizes with Fezf2 to promote direct in vivo reprogramming of upper layer cortical neurons and cortical glia towards deep-layer neuron identities.

PLoS biology·2023

Related Experiment Video

Updated: Aug 26, 2025

Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis
14:58

Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis

Published on: February 13, 2014

14.4K

Tuning the neurogenesis channel.

Nicolás Marichal1, Benedikt Berninger2

  • 1Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Neuron
|October 6, 2022
PubMed
Summary
This summary is machine-generated.

Earlier work implicated GABA in forebrain progenitor proliferation. Everlien et al. (2022) show diazepam binding inhibitor restrains GABA's neurogenesis-promoting effect, revealing a novel regulatory mechanism in brain development.

More Related Videos

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
08:52

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Published on: July 24, 2019

6.6K
Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
09:44

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

297

Related Experiment Videos

Last Updated: Aug 26, 2025

Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis
14:58

Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis

Published on: February 13, 2014

14.4K
Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
08:52

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Published on: July 24, 2019

6.6K
Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
09:44

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

297

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • The neurotransmitter GABA (gamma-aminobutyric acid) is known to influence progenitor cell proliferation in the developing forebrain.
  • Understanding the precise molecular mechanisms regulating neurogenesis is crucial for comprehending brain development and potential therapeutic interventions.

Purpose of the Study:

  • To investigate the role of diazepam binding inhibitor (DBI) in modulating GABAergic signaling during forebrain neurogenesis.
  • To elucidate how DBI affects the proliferation of neural progenitor cells influenced by GABA.

Main Methods:

  • Utilized molecular and cellular techniques to examine the interaction between DBI and GABA signaling pathways.
  • Assessed the impact of DBI on the proliferation rates of forebrain progenitor cells in vitro and/or in vivo models.

Main Results:

  • Demonstrated that diazepam binding inhibitor actively counteracts the neurogenesis-promoting effects of GABA.
  • Identified DBI as a key factor that limits the extent of GABA-driven progenitor cell proliferation.

Conclusions:

  • DBI plays a critical inhibitory role in regulating GABA's influence on forebrain neurogenesis.
  • This finding uncovers a novel mechanism by which neurogenesis is controlled, with potential implications for developmental neuroscience.