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Tumor-Derived Extracellular Vesicles: Multifunctional Entities in the Tumor Microenvironment
James W Clancy1, Crislyn D'Souza-Schorey1
1Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA; email: jclancy3@nd.edu, cdsouzas@nd.edu.
Annual Review of Pathology
|October 6, 2022
Summary
Tumor cells release extracellular vesicles (EVs) that carry bioactive molecules, influencing cancer progression and metastasis. These EVs show promise as biomarkers for cancer risk stratification and diagnosis.
Area of Science:
- Oncology
- Cell Biology
- Biochemistry
Background:
- Tumor cells communicate via extracellular vesicles (EVs) containing proteins and nucleic acids.
- EVs mediate intercellular communication within the tumor microenvironment.
- EV cargo influences cancer progression, immune evasion, and metastasis.
Purpose of the Study:
- To summarize current knowledge on EV cargo and their role in cancer progression.
- To explore the potential of EVs as biomarkers for cancer diagnostics and prognostics.
Main Methods:
- Review of recent developments in extracellular vesicle research.
- Analysis of EV cargo composition (proteins, RNAs, DNA).
- Investigation of EV impact on tumor microenvironment and cancer progression.
Main Results:
- EVs facilitate paracrine signaling and stromal cell reprogramming.
- EVs contribute to premetastatic niche formation, immune evasion, and metastasis.
- Tumor-derived EV content varies with tumor origin, stage, and therapy response.
Conclusions:
- Extracellular vesicles are key mediators of cancer progression.
- EVs hold significant potential for development into liquid biopsy biomarkers for cancer management.
Keywords:
EV cargoescarcinoma-associated fibroblastscell migrationexosomesextracellular vesiclesliquid biopsiesmicrovesiclestumor invasiontumor-infiltrating cellsMore Related Videos
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