Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.8K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.8K
Experimental RNAi02:15

Experimental RNAi

6.2K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.2K
MicroRNAs01:22

MicroRNAs

3.1K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.1K
Types of RNA01:23

Types of RNA

64.4K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
64.4K
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

6.7K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
6.7K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Steering Diels-Alder Reaction with Mechanical Force: Structure Deformation versus Electron Rearrangement.

The journal of physical chemistry. A·2026
Same author

Piezo1-mediated mechanotransduction and metabolic regulation in bone health: molecular mechanisms and implications for bone disorders.

Frontiers in cell and developmental biology·2026
Same author

Polyphasic taxonomy of entomopathogenic fungi infecting scale insects in <i>Clavicipitaceae (Hypocreales)</i> from China.

IMA fungus·2026
Same author

EXPRESSION OF CONCERN: Intracellular FGF1 promotes invasion and migration in thyroid carcinoma via HMGA1 independent of FGF receptors.

Endocrine connections·2026
Same author

Bridging metabolic reprogramming and targeted therapy: the critical role of S-palmitoylation in cancer.

Frontiers in cell and developmental biology·2026
Same author

Dietary Fiber Alleviates Gut Microbiota Dysbiosis Caused by High Bile Acids.

Journal of agricultural and food chemistry·2026

Related Experiment Video

Updated: Aug 26, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

560

Non-coding RNAs in breast cancer: Implications for programmed cell death.

Yan Luo1, Weiqiang Tang1, Shasha Xiang1

  • 1Cancer Research Institute, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, PR China.

Cancer Letters
|October 6, 2022
PubMed
Summary

Programmed cell death (PCD) regulation is vital in breast cancer. Noncoding RNAs (ncRNAs) influence PCD, offering potential as therapeutic targets and biomarkers for novel breast cancer treatments.

Keywords:
Cancer-promoting mechanismCancer-suppressing mechanismCell death modesncRNA dysregulationncRNA-based therapies

More Related Videos

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
09:24

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells

Published on: August 12, 2015

9.2K
Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.7K

Related Experiment Videos

Last Updated: Aug 26, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

560
Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
09:24

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells

Published on: August 12, 2015

9.2K
Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.7K

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Cell death is essential for development, homeostasis, and disease, with programmed cell death (PCD) being a key regulated form.
  • Dysregulation of PCD contributes to tumorigenesis, as exemplified by tumor cell resistance to apoptosis and the mechanism of action for chemotherapy.
  • Noncoding RNAs (ncRNAs) are increasingly recognized for their roles in regulating diverse biological processes, including PCD in breast cancer.

Purpose of the Study:

  • To review the diverse functions of ncRNAs in regulating programmed cell death (PCD) in breast cancer cells.
  • To explore the potential of ncRNAs as therapeutic agents and biomarkers for targeting PCD in breast cancer.

Main Methods:

  • Literature review of studies investigating ncRNAs and their involvement in breast cancer PCD.
  • Analysis of ncRNA expression patterns and their dual roles (protumorigenic/antitumorigenic) in breast cancer.

Main Results:

  • NcRNAs exhibit varied effects on breast cancer cell death, acting as either promoters or inhibitors depending on their expression.
  • NcRNAs are implicated in modulating key pathways governing PCD in breast cancer.

Conclusions:

  • Targeting ncRNAs involved in PCD presents a promising therapeutic strategy for breast cancer.
  • NcRNAs hold significant potential as biomarkers for diagnosing or predicting treatment response and as activators of PCD in breast cancer therapy.