The effect of isoxicam on neutrophil and monocyte function

1 Isoxicam was found to inhibit monocyte and neutrophil cell chemotaxis at therapeutic concentrations. 2 The effect was observed after in vitro incubation of normal cells and in vivo in patients with rheumatoid arthritis. 3 Compared to other NSAIDs studied in our laboratory, isoxicam was shown to have a broader spectrum of inhibitory action on the cells involved in the chronic inflammation associated with rheumatoid arthritis.