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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

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High-normal diastolic blood pressure as a risk factor for left ventricular diastolic dysfunction in healthy

Makiko Kimura1, Haruki Sekiguchi2,3,4,5, Ken Shimamoto1,6

  • 1Institute of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|October 6, 2022
PubMed

Insights

In healthy postmenopausal women, elevated diastolic blood pressure is a key predictor of left ventricular (LV) diastolic dysfunction. This finding highlights a potential risk factor for diastolic heart failure in this population.

Area of Science:

  • Cardiology
  • Gerontology
  • Metabolic Health

Background:

  • Left ventricular (LV) diastolic dysfunction is linked to heart failure with preserved ejection fraction.
  • Metabolic syndrome (MetS) is a known risk factor, but specific metabolic contributors to LV dysfunction in healthy postmenopausal women are unclear.

Purpose of the Study:

  • To investigate the association between LV diastolic dysfunction and MetS in postmenopausal women without comorbidities.
  • To identify cardiovascular risk factors contributing to LV diastolic dysfunction in this demographic.

Main Methods:

  • Echocardiography was used to diagnose LV diastolic dysfunction in 269 postmenopausal women.
  • Participants were free of hypertension, diabetes, LV systolic dysfunction, and other heart diseases.
  • Logistic regression analysis identified predictors of LV diastolic dysfunction.

Main Results:

  • 10.7% of participants had MetS, and 14.9% had LV diastolic dysfunction.
  • Abnormal diastolic blood pressure (OR 3.6) and age (OR 1.1) were significant predictors of LV diastolic dysfunction.
  • High-normal diastolic blood pressure emerged as the sole independent risk factor.

Conclusions:

  • Elevated diastolic blood pressure is an independent risk factor for LV diastolic dysfunction in healthy postmenopausal women.
  • Diastolic blood pressure may serve as a valuable predictor for diastolic heart failure in routine screenings.
  • Further research into metabolic factors influencing cardiac function in this population is warranted.

Keywords:
Blood pressureBody mass indexLeft ventricular dysfunctionMetabolic syndromePostmenopausal women

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