Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Symbiosis00:58

Symbiosis

29.9K
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
29.9K
Diversity of Protists II01:27

Diversity of Protists II

104
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
104
Increased Body Temperature01:25

Increased Body Temperature

751
A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
751
Patterns of Fever01:26

Patterns of Fever

2.9K
Before understanding the types and patterns of fever, it is essential to know its phases.
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antimalarial Activity of KAF156 in Falciparum and Vivax Malaria.

The New England journal of medicine·2016
Same author

Geographic distribution of amino acid mutations in DHFR and DHPS in Plasmodium vivax isolates from Lao PDR, India and Colombia.

Malaria journal·2016
Same author

The clinical impact of artemisinin resistance in Southeast Asia and the potential for future spread.

FEMS microbiology reviews·2016
Same author

Reply to Meshnick and Hastings et al.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2016
Same author

Management of relapsing Plasmodium vivax malaria.

Expert review of anti-infective therapy·2016
Same author

Antimalarial mass drug administration: ethical considerations.

International health·2016
Same journal

Genotypic analysis of Plasmodium falciparum malaria parasites in a clinical trial of RTS,S vaccination in combination with seasonal malaria chemoprevention.

Malaria journal·2026
Same journal

Less is more: modelling the impact of species-targeted versus broadcast larviciding in Anopheles funestus-dominated malaria transmission settings.

Malaria journal·2026
Same journal

'Poverty is the biggest barrier': stakeholder perspectives on social determinants of malaria in Wakiso District, Uganda.

Malaria journal·2026
Same journal

Clinical malaria recurrence and associated factors in infancy following IPTp-DP versus IPTp-SP in Busia, Uganda; a secondary analysis using the Conditional Frailty model.

Malaria journal·2026
Same journal

Prevalence of molecular markers related to artemisinin partial resistance and ACT partner drug resistance in the Plasmodium falciparum population in Kongo Central, DRC.

Malaria journal·2026
Same journal

Malaria among febrile patients during a yellow fever outbreak in Ghana: a cross-sectional study.

Malaria journal·2026
See all related articles

Related Experiment Video

Updated: Aug 26, 2025

A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting
07:27

A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting

Published on: May 16, 2013

18.8K

Severe malaria.

Nicholas J White1,2

  • 1Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. nickw@tropmedres.ac.

Malaria Journal
|October 6, 2022
PubMed
Summary
This summary is machine-generated.

Severe malaria is a leading cause of childhood death in tropical regions. Improving diagnosis with blood smear tests and treating suspected cases with artesunate and antibiotics can significantly reduce mortality.

More Related Videos

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
10:22

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

9.0K
Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors
05:28

Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors

Published on: May 12, 2022

3.1K

Related Experiment Videos

Last Updated: Aug 26, 2025

A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting
07:27

A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting

Published on: May 16, 2013

18.8K
Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
10:22

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

9.0K
Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors
05:28

Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors

Published on: May 12, 2022

3.1K

Area of Science:

  • Tropical Medicine
  • Infectious Diseases
  • Pediatrics

Background:

  • Severe malaria is a critical medical emergency and a primary cause of preventable childhood mortality in tropical nations.
  • Despite its significance, international bodies and policymakers are increasingly unaware of severe malaria, leading to its neglect in global health initiatives.
  • In sub-Saharan Africa, clinical overdiagnosis of severe malaria is prevalent, with conditions like sepsis often misidentified.

Purpose of the Study:

  • To highlight the diagnostic challenges and mortality associated with severe malaria.
  • To emphasize the need for improved diagnostic accuracy and timely treatment in severe malaria cases.
  • To advocate for increased global attention and investment in combating severe malaria.

Main Methods:

  • Review of diagnostic practices and outcomes in severe malaria cases.
  • Analysis of the impact of misdiagnosis on mortality rates.
  • Evaluation of established diagnostic tests like thin blood smear and full blood count.
  • Assessment of treatment strategies including artesunate and broad-spectrum antibiotics.

Main Results:

  • Approximately one-third of children diagnosed with severe malaria in sub-Saharan Africa are misdiagnosed, often having sepsis as the underlying cause.
  • These misdiagnosed children experience high mortality, contributing significantly to deaths attributed to severe malaria.
  • Simple diagnostic tests, such as thin blood smear examination and full blood count, enhance diagnostic specificity and prognostic assessment.
  • Early intervention with artesunate and broad-spectrum antibiotics shows potential to decrease global malaria mortality.

Conclusions:

  • Accurate diagnosis of severe malaria is crucial, as many cases are misdiagnosed, particularly with sepsis.
  • Wider implementation of simple diagnostic tests like blood smears and full blood counts is recommended.
  • Prompt administration of artesunate and broad-spectrum antibiotics for suspected severe malaria can substantially reduce child mortality in endemic areas.