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Related Experiment Video

Updated: Jul 19, 2026

The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport
13:17

The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport

Published on: March 6, 2015

Tumour cell trapping in rat mesenteric lymph nodes.

R A Cobb, H W Steer

    British Journal of Experimental Pathology
    |June 1, 1987
    PubMed
    Summary

    This study developed a rat model for mesenteric lymph node metastasis. Results show mesenteric lymph nodes effectively trap tumor cells, preventing systemic spread.

    Area of Science:

    • Oncology
    • Surgical Pathology
    • Experimental Medicine

    Background:

    • Mesenteric lymph nodes play a critical role in immune surveillance and metastasis.
    • Understanding the behavior of tumor cells within the mesenteric lymphatic system is crucial for cancer research.

    Purpose of the Study:

    • To establish a novel experimental model for studying mesenteric lymph node metastasis in rats.
    • To investigate the capacity of rat mesenteric lymph nodes to trap inoculated tumor cells.

    Main Methods:

    • Afferent mesenteric lymphatic inoculation of transplantable sarcoma cell suspensions into rats using glass microcannulae.
    • Mesenteric lymphadenectomy in a subset of rats to assess tumor cell dissemination.
    • Use of 125Iododeoxyuridine (IDUR)-labeled sarcoma cells to track cell migration.

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    Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
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    Quantification of Tumor Cell Adhesion in Lymph Node Cryosections

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    Murine Mesenteric Lymphadenectomy for Selective Disruption of Lymphatic Communication with Region-Specific Gut
    07:27

    Murine Mesenteric Lymphadenectomy for Selective Disruption of Lymphatic Communication with Region-Specific Gut

    Published on: December 30, 2025

    Related Experiment Videos

    Last Updated: Jul 19, 2026

    The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport
    13:17

    The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport

    Published on: March 6, 2015

    Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
    06:09

    Quantification of Tumor Cell Adhesion in Lymph Node Cryosections

    Published on: February 9, 2020

    Murine Mesenteric Lymphadenectomy for Selective Disruption of Lymphatic Communication with Region-Specific Gut
    07:27

    Murine Mesenteric Lymphadenectomy for Selective Disruption of Lymphatic Communication with Region-Specific Gut

    Published on: December 30, 2025

    Main Results:

    • Tumor growth was observed in 100% of inoculated mesenteric lymph nodes, with no extra-nodal spread in intact rats.
    • Rats that underwent prior mesenteric lymphadenectomy showed lung metastasis after tumor cell inoculation.
    • Radioactivity from labeled tumor cells decreased in mesenteric lymph nodes, but no cells were detected in thoracic duct lymph.

    Conclusions:

    • The rat mesenteric lymph node serves as an effective trap for circulating sarcoma cells.
    • This model provides a valuable tool for investigating lymph node metastasis dynamics and therapeutic strategies.