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Precision Medicine for Obesity
Lizeth Cifuentes1, Maria Daniela Hurtado A1,2, Jeanette Eckel-Passow3
1Precision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Abstract:
Obesity is a multifactorial disease with a variable and underwhelming weight loss response to current treatment approaches. Precision medicine proposes a new paradigm to improve disease classification based on the premise of human heterogeneity, with the ultimate goal of maximizing treatment effectiveness, tolerability, and safety. Recent advances in high-throughput biochemical assays have contributed to the partial characterization of obesity's pathophysiology, as well as to the understanding of the role that intrinsic and environmental factors, and their interaction, play in its development and progression. These data have led to the development of biological markers that either are being or will be incorporated into strategies to develop personalized lines of treatment for obesity. There are currently many ongoing initiatives aimed at this; however, much needs to be resolved before precision obesity medicine becomes common practice. This review aims to provide a perspective on the currently available data of high-throughput technologies to treat obesity.
Insights
Precision medicine offers a personalized approach to obesity treatment by utilizing high-throughput technologies and biological markers. This strategy aims to improve weight loss effectiveness and safety by accounting for individual patient differences.
Area of Science:
- Metabolic disease research
- Biochemistry
- Genomics and personalized medicine
Background:
- Obesity is a complex, multifactorial disease with limited success in current treatments.
- Human heterogeneity necessitates personalized approaches for effective disease management.
- High-throughput biochemical assays are advancing the understanding of obesity's pathophysiology.
Purpose of the Study:
- To review the application of high-throughput technologies in precision obesity medicine.
- To explore the potential of biological markers for personalized obesity treatment strategies.
- To provide a perspective on the current state and future of precision obesity care.
Main Methods:
- Literature review of high-throughput technologies and their application to obesity.
- Analysis of biological markers derived from biochemical assays.
- Examination of precision medicine principles in the context of obesity.
Main Results:
- High-throughput technologies are characterizing obesity pathophysiology and identifying key factors.
- Biological markers are emerging for personalized treatment development.
- Significant progress has been made, but challenges remain for widespread clinical adoption.
Conclusions:
- Precision medicine holds promise for improving obesity treatment outcomes.
- Further research and technological integration are needed to realize the full potential of precision obesity medicine.
- Personalized treatment strategies are crucial for maximizing effectiveness, tolerability, and safety in obesity management.
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