Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

MicroRNAs01:22

MicroRNAs

3.1K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.1K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.8K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.8K
Neural Regulation01:37

Neural Regulation

39.7K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.7K
Experimental RNAi02:15

Experimental RNAi

6.2K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trends and disparities in self-reported past-month poor mental health among individuals using cannabis in the U.S., 2016-2023.

Social psychiatry and psychiatric epidemiology·2026
Same author

Integrated Proteomics and Metabolomics Analysis Reveals Potential Pathways Underlying Onion-Mediated Regulation of Spleen Immune Function in Liangshan Black Sheep.

Veterinary sciences·2026
Same author

Toxicology-informed sequencing to optimise cancer therapy.

Lancet (London, England)·2026
Same author

Which Nudges Matter Most for Scalable Influenza Vaccination?

JAMA internal medicine·2026
Same author

Digital measurement and safety parameter analysis of the infra-acetabular screw pathway.

BMC surgery·2026
Same author

Evaluation of large language models in percutaneous coronary intervention decision-making.

Frontiers in cardiovascular medicine·2026
Same journal

Contemporary pharmacological strategies for acute peripheral facial palsy: a narrative review with clinical decision considerations.

Frontiers in neuroscience·2026
Same journal

Physical bacteria-neuron proximity and early cellular responses: a conceptual perspective.

Frontiers in neuroscience·2026
Same journal

Dynamic changes of gut microbiota during progression of three Alzheimer's disease mice models.

Frontiers in neuroscience·2026
Same journal

Evaluation of an open-face 8-channel transmit 64-channel receive 7T head coil for neuroimaging.

Frontiers in neuroscience·2026
Same journal

Acoustic stimulation in pain management: neurobiological mechanisms and clinical applications-a narrative review.

Frontiers in neuroscience·2026
Same journal

Local brain connectome parameters across the spectrum of clinical cognitive decline.

Frontiers in neuroscience·2026
See all related articles

Related Experiment Video

Updated: Aug 26, 2025

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
08:17

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

16.5K

Decoding competitive endogenous RNA regulatory network in postoperative cognitive dysfunction.

Wei Wang1, Pengwei Huo2, Lei Zhang1

  • 1Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.

Frontiers in Neuroscience
|October 7, 2022
PubMed
Summary
This summary is machine-generated.

Postoperative cognitive dysfunction (POCD) in elderly patients may involve circular RNAs. This study identified key circRNA-miRNA-mRNA networks in POCD, suggesting potential diagnostic biomarkers and therapeutic targets for this neurological complication.

Keywords:
Wnt signalingbioinformatic analysiscircRNAcompetitive endogenous RNA networkpostoperative cognitive dysfunction

More Related Videos

Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons
10:50

Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons

Published on: April 24, 2021

1.1K
Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

316

Related Experiment Videos

Last Updated: Aug 26, 2025

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
08:17

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

16.5K
Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons
10:50

Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons

Published on: April 24, 2021

1.1K
Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

316

Area of Science:

  • Neuroscience
  • Genomics
  • Molecular Biology

Background:

  • Postoperative cognitive dysfunction (POCD) is a prevalent neurological complication affecting elderly patients.
  • Circular RNAs (circRNAs) are implicated in brain function, but their role in POCD and associated regulatory networks are not well understood.

Purpose of the Study:

  • To investigate the circRNA-miRNA-mRNA competitive endogenous RNA (ceRNA) regulatory network in the context of POCD.
  • To identify potential diagnostic biomarkers and therapeutic targets for POCD.

Main Methods:

  • Utilized transcriptomic data from the Gene Expression Omnibus (GEO) datasets (GSE190880, GSE95070, GSE115440) to analyze hippocampus samples from POCD mice and controls.
  • Identified differentially expressed circRNAs, miRNAs, and mRNAs.
  • Constructed a ceRNA regulatory network and validated key RNA expression using qRT-PCR.

Main Results:

  • Identified 119 differentially expressed circRNAs, 33 miRNAs, and 49 mRNAs.
  • Confirmed enhanced expression of circ_0001634, circ_0001345, and circ_0001493.
  • Established a ceRNA network involving three circRNAs, three miRNAs, and six mRNAs, with hub mRNAs linked to hormone catabolism and Wnt signaling.

Conclusions:

  • The identified circRNA-miRNA-mRNA networks, particularly circ_0001634/miR-490-5p/Rbm47, circ_0001634/miR-490-5p/Sostdc1, circ_0001634/miR-7001-5p/Sostdc1, circ_0001345/miR-7001-5p/Sostdc1, and circ_0001493/miR-7001-5p/Sostdc1, represent novel diagnostic biomarkers and therapeutic targets for POCD.