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Vitamin E kinetics in sheep.

M Hidiroglou, K Karpinski

    The British Journal of Nutrition
    |July 1, 1987
    PubMed
    Summary

    This study on sheep found that intravenous administration of alpha-tocopherol (vitamin E) offers the highest biological availability and fastest elimination. Other routes like intramuscular, oral, and intraruminal showed varying absorption and elimination rates.

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    Area of Science:

    • Animal Science
    • Pharmacokinetics
    • Nutritional Biochemistry

    Background:

    • Alpha-tocopherol (vitamin E) is a crucial fat-soluble antioxidant.
    • Understanding its absorption and distribution is vital for animal health and nutrition.
    • Different administration routes can significantly impact vitamin E bioavailability.

    Purpose of the Study:

    • To investigate the pharmacokinetic profile of D-alpha-[5-Me-3H]tocopherol in sheep.
    • To compare the biological availability and elimination rates of alpha-tocopherol via intravenous, oral, intraruminal, and intramuscular routes.

    Main Methods:

    • Physiological doses of radiolabeled D-alpha-[5-Me-3H]tocopherol were administered to 24 sheep.
    • Blood samples were collected at various time points post-administration (up to 216 hours).
    • Pharmacokinetic analysis was performed using compartmental modeling.

    Main Results:

    • Biological availability followed the order: intravenous > intramuscular > oral > intraruminal.
    • Elimination rates were ordered: intravenous > oral > intraruminal ≈ intramuscular.
    • The intravenous route best fit a three-compartment model; others fit one- or two-compartment models.

    Conclusions:

    • Intravenous administration provides the most efficient delivery and rapid clearance of alpha-tocopherol in sheep.
    • Oral and intraruminal routes demonstrate lower bioavailability compared to parenteral administration.
    • Route of administration critically influences alpha-tocopherol pharmacokinetics in this species.

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