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Remnant cholesterol is associated with cardiovascular mortality
Kerui Zhang1, Xiangyun Qi1, Fuyu Zhu1
1Cardiovascular Research Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.
Frontiers in Cardiovascular Medicine
|October 7, 2022
Summary
Elevated remnant cholesterol (RC) is a significant predictor of cardiovascular mortality in the general population. This finding highlights RC as a crucial marker for assessing heart disease risk.
Area of Science:
- Cardiovascular Medicine
- Lipid Metabolism
- Public Health
Background:
- Circulating remnant cholesterol (RC) levels are increasingly recognized for their association with cardiovascular diseases.
- However, the independent predictive value of RC for cardiovascular mortality in the general population requires further clarification.
Purpose of the Study:
- To investigate the association between remnant cholesterol (RC) and cardiovascular mortality in a large, diverse adult population.
- To determine if RC predicts cardiovascular mortality independently of traditional cardiovascular risk factors.
Main Methods:
- Utilized data from 19,650 US adults in the National Health and Nutrition Examination Survey (NHANES) (1999-2014).
- Calculated RC using the Sampson formula from non-high-density lipoprotein cholesterol (non-HDL-C) and low-density lipoprotein cholesterol (LDL-C).
- Employed multivariate Cox regression, restricted cubic spline analysis, and subgroup analyses to assess the relationship between RC and cardiovascular mortality.
Main Results:
- Over a median follow-up of 93 months, 382 (1.9%) cardiovascular deaths occurred.
- Log remnant cholesterol (RC) was significantly associated with increased cardiovascular mortality (HR 2.82; 95% CI 1.17-6.81) in fully adjusted models.
- Higher levels of LDL-C, RC, and abnormal HDL-C were linked to a greater risk of cardiovascular mortality.
Conclusions:
- Elevated remnant cholesterol (RC) levels are independently associated with cardiovascular mortality.
- RC serves as a significant predictor of cardiovascular events, even after accounting for traditional risk factors.
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