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Visualization of Candida albicans in the Murine Gastrointestinal Tract Using Fluorescent In Situ Hybridization
Published on: November 5, 2019
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Interactions between Candida albicans and the resident microbiota
Hao Li1,2, Ming-Xing Miao2, Cheng-Lin Jia3
1Department of Pharmacy, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Frontiers in Microbiology
|October 7, 2022
Summary
Candida albicans, a common fungus, can cause infections when the balance with host microbiota is disturbed. Understanding these interactions offers new therapeutic strategies for fungal diseases.
Area of Science:
- Mycology
- Infectious Diseases
- Microbiology
Background:
- Candida albicans is a common human fungal pathogen.
- It exists as a commensal but can cause superficial to systemic infections when pathogenic.
- This switch is often linked to disruptions in the fungus-host-microbiota interaction.
Purpose of the Study:
- To review the interactions between C. albicans and host microbiota.
- To focus on these interactions in the mouth, gut, blood, and vagina.
- To identify future research directions.
Main Methods:
- Literature review of studies on Candida albicans and host microbiota.
- Analysis of interactions in various human body sites.
- Synthesis of current knowledge and identification of research gaps.
Main Results:
- C. albicans interactions with microbiota vary across different body sites.
- Perturbations in these complex interplays are key to fungal pathogenesis.
- Specific microbial communities influence C. albicans virulence.
Conclusions:
- Understanding C. albicans-microbiota interplay is crucial for deciphering fungal infection etiology.
- This knowledge can illuminate novel therapeutic approaches for fungal diseases.
- Further research into these interactions will advance clinical strategies.
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