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Updated: Aug 26, 2025
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Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
Published on: June 17, 2015
12.7K
Identifying the landscape of developmental toxicity new approach methodologies
Richard A Becker1, Enrica Bianchi2, Jessica LaRocca2
1American Chemistry Council, Washington, District of Columbia, USA.
Birth Defects Research
|October 7, 2022
Summary
A systematic review identified new approach methodologies (NAMs) for developmental toxicity testing. An interactive dashboard visualizes research trends, aiding in screening and funding for these crucial safety assessments.
Area of Science:
- Toxicology
- Developmental Biology
- Computational Biology
Background:
- Transitioning from traditional animal testing to new approach methodologies (NAMs) for in utero fetal development assessment presents challenges.
- Advances like induced pluripotent stem cell-derived models are driving progress in developmental toxicity testing.
- Increased research investment fuels the development of NAMs for toxicity screening.
Purpose of the Study:
- To conduct a systematic literature review to understand the current landscape of developmental toxicity NAMs.
- To identify NAMs for toxicity screening and potential funding opportunities.
- To inform research and development in the field of developmental toxicology.
Main Methods:
- A scoping review methodology was employed to systematically survey scientific literature from 2010-2021.
- ~18,000 references were identified and analyzed for relevant data and metadata.
- Results and metadata were extracted to create a user-friendly, interactive data visualization dashboard.
Main Results:
- A free, open-access web-based dashboard was developed using Tableau® software.
- The dashboard facilitates interactive queries and visualizations of developmental toxicity NAMs research.
- It highlights research trends, identifying areas with significant and limited focus.
Conclusions:
- The developed dashboard serves as a valuable tool for exploring the field of developmental toxicity NAMs.
- It aids in understanding research gaps and opportunities in NAMs development and application.
- The systematic review approach provides a comprehensive overview to guide future research and funding efforts.
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