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Porous biomaterials for tissue engineering: a review
Fouad Junior Maksoud1, María Fernanda Velázquez de la Paz2, Alice J Hann2
1Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu.
Porous biomaterials are crucial in tissue engineering for creating complex structures and mimicking tissue mechanics. This review covers their history, manufacturing, and diverse clinical applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Biomedical Engineering
Background:
- The field of biomaterials has seen significant growth.
- Porous biomaterials are vital for advanced biomedical applications.
- Key roles include complex structure manufacturing, mechanical property replication, cell transport, and biocompatible integration.
Purpose of the Study:
- To provide a historical overview of biomaterial development.
- To discuss current porous biomaterials and their manufacturing techniques.
- To explore clinical applications, material behaviors, advantages, and challenges.
Main Methods:
- Literature review of biomaterial development.
- Analysis of current porous biomaterial technologies.
- Discussion of clinical case studies and material properties.
Main Results:
- Porous biomaterials enable complex 3D structures and mimic host tissue mechanics.
- Interconnected pores facilitate transport of cells and macromolecules.
- Tailorable biocompatibility allows for specific host interactions.
Conclusions:
- Porous biomaterials are essential for advancing regenerative medicine and medical device technology.
- Understanding material properties and manufacturing is key to successful clinical translation.
- Ongoing research addresses challenges and expands applications of porous biomaterials.
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