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Cancer: Can CRISPR Become a Game Changer?

Sikandar Hayat Khan1

  • 1Department of Pathology, PNS Hafeez Naval Hospital, Islamabad, Pakistan.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|October 7, 2022
PubMed

Insights

CRISPR genome editing shows promise for cancer diagnostics and therapy, but faces challenges. Further improvements are needed to enhance efficiency and reduce off-target mutations for clinical application.

Area of Science:

  • Biotechnology
  • Genomics
  • Oncology

Background:

  • CRISPR technology offers powerful genome editing capabilities with potential applications in cancer diagnostics and therapy.
  • Current research shows successes in animal models and early-phase human trials for CRISPR-based cancer interventions.

Purpose of the Study:

  • To review the current state of CRISPR technology in oncology.
  • To identify limitations and areas for improvement in CRISPR-based cancer therapies.

Main Methods:

  • Literature search and analysis of existing studies on CRISPR applications in cancer.
  • Evaluation of CRISPR technology's efficacy, safety (off-target mutations), and delivery methods.

Main Results:

  • CRISPR demonstrates potential in oncology but faces significant challenges.
  • Key limitations include off-target mutations, variable efficiency, and difficulties in personalized treatment delivery.

Conclusions:

  • CRISPR technology requires further advancements in efficiency and specificity for widespread clinical use in cancer treatment.
  • Enhanced delivery systems and methods to minimize off-target mutations are crucial for realizing CRISPR's full therapeutic potential in oncology.

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