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The enigmatic triad, a clinical challenge.

María Lourdes Ruiz Rebollo1, Concepción García2, César Alberto Berrocal de la Fuente3

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Diabetic ketoacidosis (DKA), hypertriglyceridemia (HTG), and acute pancreatitis (AP) form "The Enigmatic Triad." This case report details a patient presenting with this rare triad, highlighting the ongoing challenge in establishing a definitive causal link for AP.

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Area of Science:

  • Endocrinology
  • Gastroenterology
  • Metabolic Disorders

Background:

  • The simultaneous occurrence of diabetic ketoacidosis (DKA), hypertriglyceridemia (HTG), and acute pancreatitis (AP) is a rare clinical presentation.
  • This triad, termed "The Enigmatic Triad," presents diagnostic and therapeutic challenges due to the incompletely understood causal mechanisms of AP in this context.

Purpose of the Study:

  • To report a case of a patient presenting with the rare triad of DKA, HTG, and AP.
  • To contribute to the understanding of the complex interplay between these three conditions.

Main Methods:

  • Case report presentation.
  • Review of patient's clinical data, laboratory findings, and diagnostic imaging.

Main Results:

  • The patient presented with the co-occurrence of DKA, severe HTG, and AP.
  • Clinical management focused on addressing each component of the triad.

Conclusions:

  • The Enigmatic Triad (DKA, HTG, AP) remains a challenging clinical scenario.
  • Further research is needed to elucidate the precise pathophysiology linking these conditions and guide optimal management strategies.