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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...

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Updated: Aug 26, 2025

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

Defining mast cell differentiation and heterogeneity through single-cell transcriptomics analysis.

Tahereh Derakhshan¹, Joshua A Boyce¹, Daniel F Dwyer¹

¹Jeff and Penny Vinik Center for Allergic Disease Research, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, Mass; Harvard Medical School, Boston, Mass.

The Journal of Allergy and Clinical Immunology

|October 7, 2022

Summary

This summary is machine-generated.

Mast cells (MCs) are key in inflammation and healing. Single-cell technologies reveal their diverse types and functions, offering new therapeutic targets.

Keywords:

Mast cell progenitors mast cell heterogeneity single-cell RNA-sequencing type 2 inflammation

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Area of Science:

Immunology
Cell Biology
Genomics

Background:

Mast cells (MCs) are crucial in type 2 inflammation, innate immunity, wound healing, and cancer.
MC heterogeneity arises from microenvironmental signals during progenitor cell differentiation.
Classical MC phenotyping relied on protease differences, but new technologies offer deeper insights.

Purpose of the Study:

To provide an overview of mast cell progenitor differentiation and characteristics.
To explore mast cell heterogeneity in health and disease using advanced profiling.
To highlight the impact of single-cell technologies on understanding MCs.

Main Methods:

Review of current knowledge on mast cell development and heterogeneity.
Emphasis on single-cell transcriptomics and profiling technologies.
Analysis of cellular functions and interactions within tissue microenvironments.

Main Results:

Single-cell transcriptomics reveals MC diversity beyond traditional classifications.
Microenvironmental signals significantly influence MC progenitor development and function.
Detailed cellular maps are emerging, aiding in understanding MC complexity.

Conclusions:

Single-cell profiling dramatically advances the understanding of mast cell heterogeneity.
This approach can identify novel therapeutic targets for diseases involving mast cells.
Further research can decipher complex MC interactions for targeted therapies.