Related Experiment Video
Updated: Aug 26, 2025

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
An autopsy case of hyperimmunoglobulin E syndrome with coronary fibrinoid necrotizing arteritis and an aneurysm
Ryo Sugimoto1, Naoki Yanagawa1, Mitsumasa Osakabe1
1Department of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University, Iwate, Japan.
Abstract:
We report a case of hyperimmunoglobulin (Ig) E syndrome (HIES) with a coronary artery aneurysm (CAA) in a 25-year-old Japanese man. He died suddenly due to chronic heart failure associated with HIES. We noted a CAA at the trunk of the left coronary artery and granulomatous and fibrinoid necrotizing arteritis of the middle portion of the left anterior descending during the autopsy. We speculate herein on the relationship between the aneurysm and arteritis. These findings facilitate a better understanding of the pathogenesis underlying HIES.
Related Concept Videos
Myocarditis I: Introduction
Rheumatic Heart Disease I: Introduction
Myocarditis II: Clinical Features and Diagnostic Tests
Acute Coronary Syndrome III: Diagnostic Studies
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

