Related Experiment Video
Updated: Aug 26, 2025
07:54
Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
6.9K
Malignant pleural mesothelioma in situ
Kohei Ando1, Takao Morohoshi1, Yukio Tsuura2
1Department of Thoracic Surgery, Yokosuka Kyosai Hospital, Yokosuka, Japan.
Interactive Cardiovascular and Thoracic Surgery
|October 7, 2022
Summary
Diagnosing in situ malignant pleural mesothelioma is now possible with molecular methods. This study presents the first case of total parietal pleurectomy for this condition, requiring further research for treatment validation.
Area of Science:
- Oncology
- Thoracic Surgery
- Molecular Pathology
Background:
- Malignant pleural mesothelioma (MPM) diagnosis, especially in situ, was historically difficult.
- Advances in molecular diagnostics, including P16 fluorescence in situ hybridization (FISH) and BRCA1-associated protein 1 (BAP1) immunohistochemistry, have improved early detection.
Purpose of the Study:
- To report the first known case of total parietal pleurectomy for in situ malignant pleural mesothelioma.
- To evaluate the potential of surgical intervention for early-stage MPM.
Main Methods:
- Diagnosis of in situ MPM utilizing advanced molecular techniques (P16 FISH, BAP1 IHC).
- Surgical intervention via total parietal pleurectomy.
Main Results:
- Successful diagnosis of in situ MPM was achieved.
- The first instance of total parietal pleurectomy for this specific condition was performed.
Conclusions:
- Total parietal pleurectomy was successfully performed for a case of mesothelioma in situ.
- Further follow-up and case accumulation are essential to establish total parietal pleurectomy as a viable treatment for mesothelioma in situ.
Related Concept Videos
01:30Pleural Disorders: Types and Brief Description
281
The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:
281
01:13Pleura of the Lungs
2.9K
The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
2.9K