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Vascular stiffening and endothelial dysfunction in atherosclerosis

Aukie Hooglugt1,2, Olivia Klatt1, Stephan Huveneers1

  • 1Amsterdam UMC, University of Amsterdam, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences.

Current Opinion in Lipidology
|October 7, 2022
PubMed

Insights

Aging increases arterial stiffness, a key risk factor for cardiovascular disease. Understanding endothelial dysfunction in stiffening arteries may reveal new therapeutic targets for atherosclerosis.

Area of Science:

  • Cardiovascular Science
  • Aging Research
  • Vascular Biology

Background:

  • Aging is a primary risk factor for cardiovascular disease, characterized by increased arterial stiffness.
  • Vascular stiffening compromises endothelial integrity, promoting immune cell infiltration and driving atherosclerosis.
  • Current therapeutic strategies for arterial stiffening remain limited.

Conclusions:

  • Further research into the endothelial role in stiffness-related cardiovascular disease is crucial.
  • Identifying new targets could restore endothelial function in atherosclerosis.
  • Novel interventions may complement existing treatments for cardiovascular disease.
Abstract

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