Related Experiment Video
Updated: Aug 26, 2025
Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure
Published on: August 14, 2017
Promoting Surgical Resection through Future Liver Remnant Hypertrophy
Pouya Entezari1, Beau B Toskich1, Edward Kim1
1From the Department of Radiology, Section of Interventional Radiology (P.E., B.T., E.S.H., R.S., R.J.L.), and Department of Surgery, Division of Transplant Surgery (D.C.), Northwestern University, 676 N Saint Clair St, Chicago, IL 60611-2927; Department of Radiology, Section of Interventional Radiology, Mayo Clinic Florida, Jacksonville, Fla (B.B.T.); Department of Radiology, Section of Interventional Radiology, Mount Sinai University Hospitals, New York, NY (E.K., A.S.); Department of Radiology, Section of Interventional Radiology, University of California-Los Angeles, Los Angeles, Calif (S.P.); and Department of Radiology, Mayo Clinic Rochester, Rochester, Minn (J.D.C.).
Achieving sufficient future liver remnant (FLR) is crucial for liver cancer surgery. Various interventional techniques can increase FLR size, aiding curative resection in patients with liver tumors.
Area of Science:
- Hepatobiliary Surgery
- Interventional Radiology
- Surgical Oncology
Background:
- Inadequate future liver remnant (FLR) volume is a significant limitation for curative-intent liver surgery in patients with primary or secondary liver malignancies.
- Specific FLR requirements vary based on baseline liver function, chemotherapy exposure, and underlying liver conditions like cirrhosis.
Purpose of the Study:
- To review and compare various interventional radiologic and surgical techniques for inducing FLR hypertrophy.
- To provide clinicians with insights into the technical considerations, outcomes, advantages, and disadvantages of each FLR-inducing method.
Main Methods:
- Review of interventional radiologic and surgical techniques for FLR hypertrophy.
- Discussion of portal vein ligation, portal vein embolization, radiation lobectomy, hepatic venous deprivation, and associating liver partition and portal vein ligation for staged hepatectomy (ALPPS).
Main Results:
- Each reviewed technique for FLR hypertrophy presents unique advantages and disadvantages.
- The choice of technique depends on individual patient factors and clinical scenarios.
Conclusions:
- Understanding the nuances of different FLR hypertrophy techniques is essential for optimizing patient selection and surgical outcomes.
- Evolving interventional methods offer promising solutions for patients previously ineligible for curative liver resection due to insufficient FLR.
