Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sex Linked Disorders01:43

Sex Linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reducing type II error in fMRI analysis: cluster-extent threshold simulation results and an evaluation of current methods to correct for multiple comparisons.

Cognitive neuroscience·2026
Same author

Predictive coding of cognitive processes in natural and artificial systems.

Cognitive neuroscience·2025
Same author

Resting-State Functional Connectivity With the Anterior and Posterior Hippocampus: An Analysis of fMRI Data From the Human Connectome Project.

Hippocampus·2025
Same author

False memories activate distinct brain regions in females and males.

Neuroimage. Reports·2025
Same author

Spatial memory encoding is associated with the anterior and posterior hippocampus: An fMRI activation likelihood estimation meta-analysis.

Hippocampus·2024
Same author

The hippocampus and implicit memory.

Cognitive neuroscience·2024

Related Experiment Video

Updated: Jun 28, 2026

Basics of Multivariate Analysis in Neuroimaging Data
06:35

Basics of Multivariate Analysis in Neuroimaging Data

Published on: July 24, 2010

17.0K

Sex is predicted by spatial memory multivariate activation patterns.

Dylan S Spets1, Scott D Slotnick2

  • 1Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

Learning & Memory (Cold Spring Harbor, N.Y.)
|October 7, 2022
PubMed
Summary
This summary is machine-generated.

This study used functional MRI (fMRI) to find sex differences in brain activity during spatial long-term memory tasks. Brain patterns accurately predicted sex, suggesting functional brain differences between males and females.

More Related Videos

Cross-Modal Multivariate Pattern Analysis
13:51

Cross-Modal Multivariate Pattern Analysis

Published on: November 9, 2011

20.0K
An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze
14:24

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze

Published on: July 29, 2025

476

Related Experiment Videos

Last Updated: Jun 28, 2026

Basics of Multivariate Analysis in Neuroimaging Data
06:35

Basics of Multivariate Analysis in Neuroimaging Data

Published on: July 24, 2010

17.0K
Cross-Modal Multivariate Pattern Analysis
13:51

Cross-Modal Multivariate Pattern Analysis

Published on: November 9, 2011

20.0K
An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze
14:24

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze

Published on: July 29, 2025

476

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • Debate exists regarding macroscopic sex differences in the brain.
  • Magnetic resonance imaging (MRI) is a key tool for brain measurement.
  • Cognitive neuroscience often combines data across sexes, potentially obscuring differences.

Purpose of the Study:

  • To investigate sex differences in brain activity during spatial long-term memory.
  • To determine if functional MRI (fMRI) activation patterns can predict biological sex.
  • To challenge the practice of collapsing across sex in cognitive neuroscience research.

Main Methods:

  • Utilized a spatial long-term memory task with functional MRI (fMRI).
  • Analyzed event-related patterns of brain activity within defined regions of interest.
  • Developed predictive models based on male and female brain activity patterns.

Main Results:

  • Sex was predicted with above-chance accuracy using fMRI activation patterns.
  • This marks the first successful prediction of sex from event-related fMRI data.
  • Demonstrated distinct brain activity patterns associated with spatial memory in males and females.

Conclusions:

  • Provided evidence for sex differences in brain processes underlying spatial long-term memory.
  • The findings support the existence of functional sex differences in the brain.
  • Highlights the need to consider sex as a biological variable in neuroscience research.