[5-Iododeoxyuridine as well as 5-bromodeoxyuridine induce the formation of specific dicentric chromosomes in cells...

5-iododeoxyuridine used instead of 5-bromodeoxyuridine for the induction of delayed disruption of telomeric links between chromosomes in polykaryocytes consisting of micronuclei was studied. It has been shown that treatment with 5-iododeoxyuridine (20 micrograms/ml) and colcemide (0.1 microgram/ml) for 42 hours induced the dicentric formation. Dicentrics were tested in 27% of all metaphases. This index was lower in comparison with 5-bromodeoxyuridine used for the same purpose.