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Preparation of Myeloid Derived Suppressor Cells MDSC from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting AutoMACS
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The function of myeloid-derived suppressor cells in COVID-19 lymphopenia

Taosan Li1, Fang Zheng2, Fanjun Cheng1

  • 1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

International Immunopharmacology
|October 7, 2022
PubMed

Insights

Myeloid-derived suppressor cells (MDSCs) drive lymphopenia in severe COVID-19. Targeting these cells could improve prognosis for patients with COVID-19 and lymphocytopenia.

Area of Science:

  • Immunology
  • Virology
  • Public Health

Background:

  • COVID-19 pandemic poses a global public health threat.
  • Lymphopenia is a hallmark of severe COVID-19, particularly in older adults, and is linked to disease severity.
  • Understanding lymphocytopenia mechanisms is crucial for reducing COVID-19 mortality.

Purpose of the Study:

  • To analyze research on myeloid-derived suppressor cells (MDSCs) in COVID-19 lymphopenia.
  • To discuss the immunopathologic changes associated with MDSCs in this context.
  • To identify prospective therapeutic targets for COVID-19 lymphocytopenia.

Main Methods:

  • Review of existing scientific literature on MDSCs and COVID-19.
  • Analysis of immunopathologic mechanisms.
  • Identification of potential therapeutic strategies.

Main Results:

  • MDSCs are confirmed as key mediators of lymphopenia in COVID-19.
  • MDSCs possess potent T-cell suppressive capabilities, influencing disease progression.
  • Targeting MDSCs shows promise for improving COVID-19 outcomes.

Conclusions:

  • MDSCs play a critical role in the pathogenesis of COVID-19-associated lymphopenia.
  • Therapeutic strategies focused on MDSCs may offer a novel approach to managing severe COVID-19.
  • Further research into MDSC-targeted therapies is warranted for COVID-19 lymphocytopenia.

Keywords:
COVID-19LymphopeniaMyeloid-derived suppressor cells

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