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Related Experiment Video

Updated: Aug 26, 2025

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

Developing a novel device, Eggcell, to improve temperature stability during oocyte collection for IVF.

Nilendran Prathalingam¹, Louise Hyslop¹, Michael Cole²

¹Newcastle Fertility Centre at Life, Newcastle Hospitals NHS Trust, Newcastle upon Tyne, NE1 4EP, UK.

Reproductive Biomedicine Online

|October 7, 2022

Summary

A new device, the Eggcell, maintains stable temperatures for aspirated follicular fluid during oocyte retrieval. This innovation protects oocytes (egg cells) and their fertilization potential.

Keywords:

Aspiration needle Egg collection Follicular fluid IVF Oocyte Temperature

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Last Updated: Aug 26, 2025

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

Human Egg Maturity Assessment and Its Clinical Application

Human Egg Maturity Assessment and Its Clinical Application

Published on: August 19, 2019

Vitrification of In Vitro Matured Oocytes Collected from Adult and Prepubertal Ovaries in Sheep

Vitrification of In Vitro Matured Oocytes Collected from Adult and Prepubertal Ovaries in Sheep

Published on: July 10, 2021

Area of Science:

Reproductive biology
Medical device engineering

Background:

Oocyte retrieval procedures can expose oocytes to temperature fluctuations.
Maintaining a stable physiological temperature is crucial for oocyte viability.

Purpose of the Study:

To investigate temperature changes during standard oocyte retrieval.
To design and validate a novel device, Eggcell, to minimize temperature fluctuations.

Main Methods:

Mock oocyte retrievals were conducted to measure temperature changes.
Laboratory validation of the Eggcell device was performed.
Human participants (n=15) were involved in initial safety and applicability testing.

Main Results:

Eggcell successfully maintained follicular fluid temperature within the physiological range.
No loss or damage to oocytes (cumulus-oocyte complexes, COCs) was observed in 180 retrievals.
Fertilization rates, blastocyst development, and clinical outcomes were not compromised.

Conclusions:

The Eggcell device demonstrates successful initial development for temperature-stable oocyte retrieval.
Further comparative studies are required to evaluate clinical outcomes against standard methods.