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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
[Multi-omics research contributes to early screening, diagnosis and treatment of liver cancer]
1Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Guangdong Provincial Institute of Liver Diseases, Guangzhou 510515, China.
Abstract:
In 2016, the World Health Organization set an ambitious goal of reducing viral hepatitis-related deaths by 65% by 2030. The key to this goal is to reduce viral hepatitis-related HCC deaths. Liver cancer is the fourth most common malignant tumor and the second leading cause of cancer death in China. The onset of HCC is insidious, and most patients are already in the middle and late stage when diagnosed. Despite the great progress on management of HCC, the therapeutic effect and prognosis of HCC are still unsatisfactory. Therefore, multi-dimensional and comprehensive analysis of the mechanism of liver cancer, improving the early screening, diagnosis and treatment rate of liver cancer are the key points of reducing the harm of liver cancer in China. In recent years, multi-omics studies have been widely applied in the field of liver cancer, providing a basis for the pathogenesis of liver cancer, early detection and diagnosis, development of individual treatment strategies and prognosis assessment. This issue will focus on the application of genomics, proteomics, metabolomics and imaging omics in early screening, diagnosis and treatment of liver cancer.
Insights
Reducing viral hepatitis-related deaths, particularly liver cancer (HCC), is crucial. Multi-omics approaches offer new strategies for early screening, diagnosis, and treatment of HCC.
Area of Science:
- Oncology
- Genetics
- Biochemistry
Background:
- Viral hepatitis is a major cause of liver cancer (HCC), a leading cause of cancer death in China.
- HCC is often diagnosed at late stages, leading to poor prognosis despite treatment advancements.
- Comprehensive analysis of HCC mechanisms and improved early detection are vital for reducing its impact.
Purpose of the Study:
- To highlight the critical role of reducing viral hepatitis-related deaths in achieving global health goals.
- To emphasize the need for multi-dimensional analysis of liver cancer mechanisms.
- To explore the application of multi-omics in improving early screening, diagnosis, and treatment of HCC.
Main Methods:
- Review of multi-omics studies including genomics, proteomics, metabolomics, and imaging omics.
- Focus on applications in early screening, diagnosis, and treatment strategies for liver cancer.
- Analysis of current progress and future directions in HCC management.
Main Results:
- Multi-omics studies provide a foundation for understanding HCC pathogenesis.
- These approaches aid in early detection, personalized treatment development, and prognosis assessment.
- The integration of various omics data is key to advancing HCC care.
Conclusions:
- Multi-omics strategies are essential for advancing the fight against liver cancer.
- Improved early screening and diagnosis through omics will enhance patient outcomes.
- Personalized treatment strategies based on omics data hold promise for HCC management.
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