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Updated: Aug 26, 2025

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[Mechanisms of Extracellular Vesicles Involved in Multiple Myeloma --Review]

Yi-Hui Guo1, Jia-Wei Xu1, Hui Song1

  • 1Graduate School of Guangxi University of Chinese Medicine, Nanning 530001， Guangxi Zhuang Autonomous Region, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|October 8, 2022
PubMed

Insights

Extracellular vesicles (EVs) are implicated in multiple myeloma (MM) progression by mediating interactions within the bone marrow microenvironment. Understanding EV mechanisms may reveal new therapeutic and prognostic strategies for this hematologic tumor.

Area of Science:

  • Hematologic oncology
  • Cell biology
  • Cancer research

Background:

  • Multiple myeloma (MM) is a hematologic malignancy driven by clonal plasma cells.
  • The precise pathogenesis of MM remains incompletely understood.
  • Extracellular vesicles (EVs) are cell-released structures involved in intercellular communication.

Purpose of the Study:

  • To review the mechanisms by which EVs influence multiple myeloma.
  • To provide insights for novel MM treatment and prognostic stratification strategies.

Main Methods:

  • Literature review of recent research on EVs and MM.

Main Results:

  • EVs facilitate communication between myeloma cells and the bone marrow microenvironment.
  • EVs contribute to the progression of multiple myeloma.
  • EVs can transfer biologically active molecules, influencing target cells.

Conclusions:

  • EVs play a significant role in the pathogenesis and progression of multiple myeloma.
  • Further research into EV mechanisms offers potential for developing new MM therapies.
  • EVs may serve as biomarkers for prognostic stratification in MM patients.
Keywords:
biomarkerextracellular vesiclemultiple myeloma

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