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Effect of ceftriaxone on intestinal transit time
Mehmet Arpacık1, Zeliha Akış Yıldız2
1Pediatric Surgery, Pediatric Burn Center, Umraniye Training and Research Hospital, Istanbul, Turkey.
Fundamental & Clinical Pharmacology
|October 8, 2022
Summary
Ceftriaxone significantly slows down intestinal transit in rats. This antibiotic prolongs both small and large intestine transit times, impacting overall digestive system function.
Area of Science:
- Pharmacology
- Gastroenterology
- Animal Studies
Background:
- Ceftriaxone is known to affect gallbladder and ileal contractility.
- Previous research indicates ceftriaxone can induce biliary sludge and pseudolithiasis.
- The impact of ceftriaxone on intestinal transit time remains uninvestigated.
Purpose of the Study:
- To investigate the effect of ceftriaxone on intestinal transit time in a rat model.
- To determine if ceftriaxone administration alters the speed of gastrointestinal transit.
Main Methods:
- Sixteen rats were divided into two groups: a study group (n=8) receiving 100 mg/kg ceftriaxone intramuscularly for 7 days, and a control group (n=8) receiving distilled water.
- Barium sulfate mixed with saline was administered orally on the seventh day.
- Barium transit was monitored using serial digital X-ray imaging at various time points.
Main Results:
- Ceftriaxone significantly prolonged small intestine transit time.
- Large intestine transit time was also significantly extended in the ceftriaxone group.
- Complete colonic transit was observed in 100% of control rats by 6 hours, versus 0% in the ceftriaxone group.
Conclusions:
- Ceftriaxone administration significantly delays intestinal transit.
- The findings suggest ceftriaxone impacts gastrointestinal motility.
- Further research is warranted to understand the clinical implications of ceftriaxone-induced transit changes.
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