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Aggregation-Seeding Forms of α-Synuclein Are Not Detected in Acute Coronavirus Disease 2019 Cerebrospinal Fluid

Marco J Russo1,2, Karen MacLeod3, Jennifer Lamoureux3

  • 1The Marlene and Paolo Fresco Institute for Parkinson's & Movement Disorders, Departments of Neurology and Neuroscience and Physiology, Neuroscience Institute, The Parekh Center for Interdisciplinary Neurology, NYU Grossman School of Medicine, New York, New York, USA.

Movement Disorders : Official Journal of the Movement Disorder Society
|October 8, 2022
PubMed
Abstract

No abstract available in PubMed .

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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