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Updated: Aug 26, 2025

In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells
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Tumor Derived Extracellular Vesicles Modulate Gene Expression in T cells

Alejandro Pando1, Christoph Schorl2, Loren D Fast3

  • 1Warren Alpert School of Medicine at Brown University and Division of Hematology/Oncology, Rhode Island Hospital, Providence, RI, United States; Center for Biomedical Engineering, Brown University, Providence, RI, United States.

Gene
|October 8, 2022
PubMed
Summary

Acute myeloid leukemia (AML) derived extracellular vesicles (EVs) alter gene expression in T cells, impacting immune regulation. CD8+ T cells showed significant changes in proliferation and differentiation pathways due to AML EVs.

Keywords:
ExosomesExtracellular vesiclesImmunologyImmunoregulationImmunotherapyMicrovesiclesTumor derived EVs

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