Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

480
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
480
Working Memory01:24

Working Memory

414
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
414

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ripple contributions to human memory: making the spiking content count.

Nature reviews. Neuroscience·2025
Same author

Online self-evaluation of fMRI-based neurofeedback performance.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2024
Same author

Pronouns reactivate conceptual representations in human hippocampal neurons.

Science (New York, N.Y.)·2024
Same author

Theta-phase dependent neuronal coding during sequence learning in human single neurons.

Nature communications·2021
Same author

Human Hippocampal Neurons Track Moments in a Sequence of Events.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2021
Same author

Concurrent human TMS-EEG-fMRI enables monitoring of oscillatory brain state-dependent gating of cortico-subcortical network activity.

Communications biology·2020
Same journal

On the clinical anatomy of technological cognition.

Cognitive neuroscience·2026
Same journal

Increasing statistical power in functional MRI through permutation and multivariate statistics.

Cognitive neuroscience·2026
Same journal

fMRI research: do we need statistically better studies, larger studies, or no more studies?

Cognitive neuroscience·2026
Same journal

Catching the drift: EEG microstate dynamics resemble time-on-task changes in mind wandering and sustained attention.

Cognitive neuroscience·2026
Same journal

Toward a cognitive neuroscience of technology.

Cognitive neuroscience·2026
Same journal

What behavioral relevance is (not).

Cognitive neuroscience·2026
See all related articles

Related Experiment Video

Updated: Aug 26, 2025

Hippocampal Insulin Microinjection and In vivo Microdialysis During Spatial Memory Testing
10:32

Hippocampal Insulin Microinjection and In vivo Microdialysis During Spatial Memory Testing

Published on: January 11, 2013

16.6K

Hippocampal activity in working memory tasks: sparse, yet relevant.

Judith C Peters1,2,3, Joel Reithler1,2,3

  • 1Cognitive Neuroscience Department, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands.

Cognitive Neuroscience
|October 9, 2022
PubMed
Summary
This summary is machine-generated.

The hippocampus may play a role in working memory (WM), despite some fMRI studies suggesting otherwise. Intracranial and lesion data indicate its involvement, prompting new research directions.

Keywords:
Working memoryfMRIhippocampusintracranial electrophysiologylong-term memoryshort-term memorysingle neuron

More Related Videos

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.3K
An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze
14:24

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze

Published on: July 29, 2025

476

Related Experiment Videos

Last Updated: Aug 26, 2025

Hippocampal Insulin Microinjection and In vivo Microdialysis During Spatial Memory Testing
10:32

Hippocampal Insulin Microinjection and In vivo Microdialysis During Spatial Memory Testing

Published on: January 11, 2013

16.6K
Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.3K
An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze
14:24

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze

Published on: July 29, 2025

476

Area of Science:

  • Neuroscience
  • Cognitive Psychology

Background:

  • Recent research suggests the hippocampus is involved in working memory (WM).
  • A critical review of fMRI findings concluded that WM does not activate the hippocampus.

Purpose of the Study:

  • To extend the review of hippocampal involvement in WM by incorporating intracranial and lesion research.
  • To reconcile conflicting findings regarding the hippocampus and WM.

Main Methods:

  • Review of human intracranial and lesion research.
  • Analysis of findings in relation to conventional fMRI limitations.

Main Results:

  • Human intracranial and lesion studies suggest hippocampal contributions to WM, particularly beyond novelty encoding.
  • These contributions are challenging to detect with standard fMRI techniques.

Conclusions:

  • The hippocampus likely plays a role in working memory, though its detection is limited by current fMRI methods.
  • Future research utilizing advanced fMRI techniques and focusing on shared memory mechanisms is promising.