Related Experiment Video

Updated: Aug 26, 2025

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

2.9K

Cost-Effectiveness of Pediatric Universal Screening for Familial Hypercholesterolemia in Argentina

María B Araujo1, María Clara Zerbino2

  • 1Nutrition Department, Hospital Garrahan, Ciudad Autónoma de Buenos Aires, Argentina.

Value in Health Regional Issues
|October 9, 2022
PubMed

Insights

Universal screening for familial hypercholesterolemia in children is cost-effective in Argentina. Early diagnosis through this method significantly increases life-years gained, making it a valuable health technology.

Area of Science:

  • Public Health
  • Health Economics
  • Pediatrics

Background:

  • Familial hypercholesterolemia (FH) is an underdiagnosed genetic disorder leading to premature cardiovascular disease.
  • Early diagnosis and treatment of FH can significantly reduce long-term health risks.

Purpose of the Study:

  • To evaluate the cost-effectiveness of universal pediatric screening for FH in Argentina.
  • To compare universal screening with the existing diagnostic approach.

Main Methods:

  • A probabilistic model was used to compare universal screening at age 6 with the previous diagnostic situation.
  • The study adopted the perspective of the Argentine public healthcare system, considering direct costs and life-years gained (LYG) and quality-adjusted life-years (QALYs).
  • A 60-year time horizon was used, including avoided costs of prevented coronary events and sensitivity analyses.

Main Results:

  • Each identified child gained an average of 8.14 life-years.
  • The incremental cost-effectiveness ratio (ICER) was $1465.35 USD/LYG and $1726.50 USD/LYG at a 5% discount rate.
  • The ICER represented 10%-17% of Argentina's per capita GDP and was below the minimum annual retirement income.

Conclusions:

  • Pediatric universal screening for familial hypercholesterolemia is a cost-effective health technology in Argentina.
  • Implementing universal screening can lead to significant improvements in life expectancy and quality of life.
Abstract

Keywords:
cost-effectiveness analysisdiagnosisfamilial hypercholesterolemiapediatric universal screeningpediatrics

More Related Videos

Universal Screening for Prevention of Reading, Writing, and Math Disabilities in Spanish14:43

Universal Screening for Prevention of Reading, Writing, and Math Disabilities in Spanish

Published on: July 18, 2020

8.1K
A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes10:56

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

Published on: September 15, 2018

8.2K

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
23
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
31
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
269
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
31
Preventive Healthcare Services01:30

Preventive Healthcare Services

Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
1.1K
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
646