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Expression of soluble ST2 in patients with essential hypertension and its relationship with left ventricular

Peng Wei1, Liang Liu1, Xiaoqing Wang1

  • 1Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.

ESC Heart Failure
|October 9, 2022
PubMed

Insights

Elevated soluble ST2 (sST2) levels are linked to left ventricular hypertrophy (LVH) in essential hypertension (EH). sST2 is an independent risk factor and potential biomarker for diagnosing hypertensive LVH.

Area of Science:

  • Cardiology
  • Biomarker Discovery
  • Hypertension Research

Background:

  • Left ventricular hypertrophy (LVH) in essential hypertension (EH) increases cardiovascular risk.
  • Accurate diagnostic methods for hypertensive LVH are currently limited.
  • Soluble ST2 (sST2) is a potential biomarker for cardiovascular conditions.

Purpose of the Study:

  • To investigate the association between serum sST2 levels and LVH in patients with EH.
  • To determine if sST2 can serve as a specific biomarker for identifying LVH in EH.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) to measure serum sST2 levels.
  • Pearson correlation, logistic regression, and ROC curve analysis were employed.
  • Patients were categorized into LVH and non-LVH groups based on established criteria.

Main Results:

  • EH patients with LVH exhibited significantly higher sST2 levels compared to those without LVH (P < 0.001).
  • sST2 levels showed a positive correlation with left ventricular mass index (r = 0.454, P < 0.001).
  • sST2 was identified as an independent risk factor for LVH in EH (OR = 2.990, P < 0.001), with an ROC AUC of 0.767.

Conclusions:

  • Increased sST2 levels are significantly associated with LVH in EH patients.
  • sST2 functions as an independent risk factor for hypertensive LVH.
  • sST2 demonstrates potential as a diagnostic biomarker for LVH in essential hypertension.
Abstract

Keywords:
Essential hypertension (EH)Left ventricular hypertrophy (LVH)Soluble ST2

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